The impact of quorum sensing on the virulence of Aeromonas hydrophila and Aeromonas salmonicida towards burbot (Lota lota L.) larvae.
Identifieur interne : 000192 ( Main/Exploration ); précédent : 000191; suivant : 000193The impact of quorum sensing on the virulence of Aeromonas hydrophila and Aeromonas salmonicida towards burbot (Lota lota L.) larvae.
Auteurs : F M I. Natrah [Belgique] ; Md Iftakharul Alam ; Sushant Pawar ; A Shiri Harzevili ; Nancy Nevejan ; Nico Boon ; Patrick Sorgeloos ; Peter Bossier ; Tom DefoirdtSource :
- Veterinary microbiology [ 1873-2542 ] ; 2012.
Descripteurs français
- KwdFr :
- Aeromonas hydrophila (pathogénicité), Aeromonas salmonicida (pathogénicité), Animaux (MeSH), Détection du quorum (physiologie), Gadiformes (MeSH), Infections bactériennes à Gram négatif (microbiologie), Infections bactériennes à Gram négatif (mortalité), Infections bactériennes à Gram négatif (médecine vétérinaire), Maladies des poissons (microbiologie), Maladies des poissons (mortalité), Microalgues (physiologie).
- MESH :
- microbiologie : Infections bactériennes à Gram négatif, Maladies des poissons.
- mortalité : Infections bactériennes à Gram négatif, Maladies des poissons.
- médecine vétérinaire : Infections bactériennes à Gram négatif.
- pathogénicité : Aeromonas hydrophila, Aeromonas salmonicida.
- physiologie : Détection du quorum, Microalgues.
- Animaux, Gadiformes.
English descriptors
- KwdEn :
- Aeromonas hydrophila (pathogenicity), Aeromonas salmonicida (pathogenicity), Animals (MeSH), Fish Diseases (microbiology), Fish Diseases (mortality), Gadiformes (MeSH), Gram-Negative Bacterial Infections (microbiology), Gram-Negative Bacterial Infections (mortality), Gram-Negative Bacterial Infections (veterinary), Microalgae (physiology), Quorum Sensing (physiology).
- MESH :
- microbiology : Fish Diseases, Gram-Negative Bacterial Infections.
- mortality : Fish Diseases, Gram-Negative Bacterial Infections.
- pathogenicity : Aeromonas hydrophila, Aeromonas salmonicida.
- physiology : Microalgae, Quorum Sensing.
- veterinary : Gram-Negative Bacterial Infections.
- Animals, Gadiformes.
Abstract
In this study, the link between quorum sensing in Aeromonas spp. and its virulence towards burbot (Lota lota) was investigated. High mortality occurred in burbot juveniles challenged with Aeromonas salmonicida HN-00, but not in juveniles challenged with Aeromonas hydrophila AH-1N. Meanwhile, both A. hydrophila AH-1N and A. salmonicida HN-00 were virulent towards larvae. The effect of quorum sensing on the virulence of A. hydrophila AH-1N towards burbot larvae was further investigated using quorum sensing mutants (N-(butyryl)-L-homoserine lactone production and receptor mutants). Challenge with these mutants resulted in higher survival of burbot larvae when compared to challenge with the wild type, and the addition of the signal molecule N-butyryl-L-homoserine lactone restored the virulence of the quorum sensing production mutant. Moreover, quorum sensing inhibitors protected the burbot larvae from both Aeromonas strains. Finally, the freshwater micro-algae Chlorella saccharophila and Chlamydomonas reinhardtii, which are able to interfere with quorum sensing, also protected burbot from the pathogens. However, QS interference was unlikely to be the only mechanism. This study revealed that the virulence of Aeromonas spp. towards burbot is regulated by quorum sensing and that quorum sensing inhibitors and micro-algae are promising biocontrol agents.
DOI: 10.1016/j.vetmic.2012.03.014
PubMed: 22465799
Affiliations:
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Le document en format XML
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Natrah</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Aquaculture &Artemia Reference Center, Ghent University, Rozier 44, 9000 Gent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Aquaculture &Artemia Reference Center, Ghent University, Rozier 44, 9000 Gent</wicri:regionArea><placeName><region type="province" nuts="2">Province de Flandre-Orientale</region><settlement type="city">Gand</settlement></placeName><orgName type="university">Université de Gand</orgName></affiliation></author><author><name sortKey="Alam, Md Iftakharul" sort="Alam, Md Iftakharul" uniqKey="Alam M" first="Md Iftakharul" last="Alam">Md Iftakharul Alam</name></author><author><name sortKey="Pawar, Sushant" sort="Pawar, Sushant" uniqKey="Pawar S" first="Sushant" last="Pawar">Sushant Pawar</name></author><author><name sortKey="Harzevili, A Shiri" sort="Harzevili, A Shiri" uniqKey="Harzevili A" first="A Shiri" last="Harzevili">A Shiri Harzevili</name></author><author><name sortKey="Nevejan, Nancy" sort="Nevejan, Nancy" uniqKey="Nevejan N" first="Nancy" last="Nevejan">Nancy Nevejan</name></author><author><name sortKey="Boon, Nico" sort="Boon, Nico" uniqKey="Boon N" first="Nico" last="Boon">Nico Boon</name></author><author><name sortKey="Sorgeloos, Patrick" sort="Sorgeloos, Patrick" uniqKey="Sorgeloos P" first="Patrick" last="Sorgeloos">Patrick Sorgeloos</name></author><author><name sortKey="Bossier, Peter" sort="Bossier, Peter" uniqKey="Bossier P" first="Peter" last="Bossier">Peter Bossier</name></author><author><name sortKey="Defoirdt, Tom" sort="Defoirdt, Tom" uniqKey="Defoirdt T" first="Tom" last="Defoirdt">Tom Defoirdt</name></author></analytic><series><title level="j">Veterinary microbiology</title><idno type="eISSN">1873-2542</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aeromonas hydrophila (pathogenicity)</term><term>Aeromonas salmonicida (pathogenicity)</term><term>Animals (MeSH)</term><term>Fish Diseases (microbiology)</term><term>Fish Diseases (mortality)</term><term>Gadiformes (MeSH)</term><term>Gram-Negative Bacterial Infections (microbiology)</term><term>Gram-Negative Bacterial Infections (mortality)</term><term>Gram-Negative Bacterial Infections (veterinary)</term><term>Microalgae (physiology)</term><term>Quorum Sensing (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aeromonas hydrophila (pathogénicité)</term><term>Aeromonas salmonicida (pathogénicité)</term><term>Animaux (MeSH)</term><term>Détection du quorum (physiologie)</term><term>Gadiformes (MeSH)</term><term>Infections bactériennes à Gram négatif (microbiologie)</term><term>Infections bactériennes à Gram négatif (mortalité)</term><term>Infections bactériennes à Gram négatif (médecine vétérinaire)</term><term>Maladies des poissons (microbiologie)</term><term>Maladies des poissons (mortalité)</term><term>Microalgues (physiologie)</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Infections bactériennes à Gram négatif</term><term>Maladies des poissons</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Fish Diseases</term><term>Gram-Negative Bacterial Infections</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Fish Diseases</term><term>Gram-Negative Bacterial Infections</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections bactériennes à Gram négatif</term><term>Maladies des poissons</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections bactériennes à Gram négatif</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Aeromonas hydrophila</term><term>Aeromonas salmonicida</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Aeromonas hydrophila</term><term>Aeromonas salmonicida</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Détection du quorum</term><term>Microalgues</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Microalgae</term><term>Quorum Sensing</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Gram-Negative Bacterial Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Gadiformes</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Gadiformes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study, the link between quorum sensing in Aeromonas spp. and its virulence towards burbot (Lota lota) was investigated. High mortality occurred in burbot juveniles challenged with Aeromonas salmonicida HN-00, but not in juveniles challenged with Aeromonas hydrophila AH-1N. Meanwhile, both A. hydrophila AH-1N and A. salmonicida HN-00 were virulent towards larvae. The effect of quorum sensing on the virulence of A. hydrophila AH-1N towards burbot larvae was further investigated using quorum sensing mutants (N-(butyryl)-L-homoserine lactone production and receptor mutants). Challenge with these mutants resulted in higher survival of burbot larvae when compared to challenge with the wild type, and the addition of the signal molecule N-butyryl-L-homoserine lactone restored the virulence of the quorum sensing production mutant. Moreover, quorum sensing inhibitors protected the burbot larvae from both Aeromonas strains. Finally, the freshwater micro-algae Chlorella saccharophila and Chlamydomonas reinhardtii, which are able to interfere with quorum sensing, also protected burbot from the pathogens. However, QS interference was unlikely to be the only mechanism. This study revealed that the virulence of Aeromonas spp. towards burbot is regulated by quorum sensing and that quorum sensing inhibitors and micro-algae are promising biocontrol agents.</div></front></TEI><affiliations><list><country><li>Belgique</li></country><region><li>Province de Flandre-Orientale</li></region><settlement><li>Gand</li></settlement><orgName><li>Université de Gand</li></orgName></list><tree><noCountry><name sortKey="Alam, Md Iftakharul" sort="Alam, Md Iftakharul" uniqKey="Alam M" first="Md Iftakharul" last="Alam">Md Iftakharul Alam</name><name sortKey="Boon, Nico" sort="Boon, Nico" uniqKey="Boon N" first="Nico" last="Boon">Nico Boon</name><name sortKey="Bossier, Peter" sort="Bossier, Peter" uniqKey="Bossier P" first="Peter" last="Bossier">Peter Bossier</name><name sortKey="Defoirdt, Tom" sort="Defoirdt, Tom" uniqKey="Defoirdt T" first="Tom" last="Defoirdt">Tom Defoirdt</name><name sortKey="Harzevili, A Shiri" sort="Harzevili, A Shiri" uniqKey="Harzevili A" first="A Shiri" last="Harzevili">A Shiri Harzevili</name><name sortKey="Nevejan, Nancy" sort="Nevejan, Nancy" uniqKey="Nevejan N" first="Nancy" last="Nevejan">Nancy Nevejan</name><name sortKey="Pawar, Sushant" sort="Pawar, Sushant" uniqKey="Pawar S" first="Sushant" last="Pawar">Sushant Pawar</name><name sortKey="Sorgeloos, Patrick" sort="Sorgeloos, Patrick" uniqKey="Sorgeloos P" first="Patrick" last="Sorgeloos">Patrick Sorgeloos</name></noCountry><country name="Belgique"><region name="Province de Flandre-Orientale"><name sortKey="Natrah, F M I" sort="Natrah, F M I" uniqKey="Natrah F" first="F M I" last="Natrah">F M I. 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